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KMID : 0438219720090010299
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Korea University Medical Journal
1972 Volume.9 No. 1 p.299 ~ p.312
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Histopathological Change of the Rat Kidney Following Temporary Ligation of the Renal Artery
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Abstract
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It was reported that, the changes in the nephrons following the ischemia are different from each other according to the duration of the arterial ligation, and regeneration of the tissue may fail if the ligation is continued more than 2 hours. This report is concerned with the histological changes of the rat kidney after temporary ligation of the unilateral renal artery. Alkaline phosphatase, which is accumulated in the tubular epithelium, was compared with those of control group histochemically. Results were as follows:
1. Pinkish fluid retention was noted in the Bowman´s space transiently, and disappeared after two days without residual morphologic change in the glomeruli.
2. Degenerative changes, such as edema or necrosis of the tubular epithelium, were seen within 2 days, then gradually the cells regenerated. Even after the renal tubular epithelium had completely regenerated, hyaline cast remained for a relatively longer period.
3. Vascular walls showed corrugation of the intima and vacuolization in the media within 2 days and returned to normal within 10 days. Tubular epithelial cells and vascular wall showed identical regenerative changes chronologically.
4. Alkaline phosphatase in the tubular epithelium thus appeared completely before the histological changes have occurred in the early stage, and gradually reappeared in the regenerating epithelial cells. Disappearance of alkaline phosphatase preceded the morphologic changes, and appearance followed the morphologic regeneration.
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